Bioactive Compounds from Spirastrella Inconstans Against Wound Infection

Mohankumar A and Tamil Selvi S

Journal of Asian Scientific Research, 2012, vol. 2, issue 1, 31-39

Abstract: Marine invertebrates, in particular sponge (Spirastrella inconstans), represent a source of a wide range of secondary metabolites, many of which have been attributed to various defensive capabilities against CA-MRSA (Community associated- Methicillin Resistant Staphylococcus aureus) obtained from wound infection among fisherman community. In this work sponge-derived low-molecular peptide-like compounds and associated analogs are investigated for bioactivity and pharmacological targets. 3,000 Da molecular weight of protein was isolated by SDS-PAGE. Amount of protein from Spirastrella inconstans was estimated by UV-Vis spectrometer were analysed by IR and UV spectrum. Absorption value obtained by UV spectrum using TECHCOMP 8500 spectrophotometer was 1.7141. Further confirmation of isolated compound was carried out by HPLC analysis as 254 nm wave length and 13C and 1H NMR. Scanning Electron Microscope (SEM) with constant voltage of 20 kV at X 850 illumination shows 20 μm between the compounds, at X 270 illumination 50 μm, at 2,300 X illumination 10 μm, at 6,000 X illumination 2 μm, at 2,700 illumination 5 μm confirms the compound by structural elucidation as glutamic acid. The novel compound in lyophilized form can favor fibroblast proliferation with collagen production, in the therapy for the healing of tendon lesions and of wounds by acting against MRSA.

Keywords: Bioactive compound; Marine sponge; Glutamic acid; Marine drugs (search for similar items in EconPapers)
Date: 2012
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