Role of Gata-4 Transcription Factor Associated With B-Type Natriuretic Peptides in Heart Failure

Fehmida Farid Khan and Sobia Tabassum

Journal of Asian Scientific Research, 2013, vol. 3, issue 2, 204-213

Abstract: Congestive heart failure is a condition in which heart loses its ability to fill with or pump sufficient amount of blood through the body. Two cardiac natriuretic peptides aterial natriuretic peptide and brain natriuretic peptide are secreted by the heart with a homologous structure. The level of brain natriuretic peptide surges in Heart Failure so brain natriuretic peptide level is used to diagnose Heart failure. Brain natriuretic peptide physiology is exaggerated by NPPB sequence variants, possibly via transcriptional regulation. The GATA cofactors are involved in the regulation of ANP and BNP promoters and a single mutation in the GATA -4 leads towards the diseases linked with heart. Mutations of GATA 4 transcription factor in promoter region of brain natriuretic peptide may cause increase level of brain natriuretic peptide.

Keywords: CCF (Congestive cardiac failure); CHF (Congestive heart failure); BNP (brain natriuretic peptide); ANP (Aterial natriuretic peptide); NPPB (Natriuretic peptide precursor B); ISO (Isoproterenol); NYHA (New York heart association). (search for similar items in EconPapers)
Date: 2013
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