Synthesis and Study of 1,2,4-Triazine and Thiadiazoles Based Derivatives of S-Triazine as Antimicrobial Agents

G. M Malik () and Talha V Patel ()

Journal of Asian Scientific Research, 2017, vol. 7, issue 6, 214-223

Abstract: Some new substituted 1,3,5 triazine derivatives with 4-amino-6-(tert-butyl)-3-(methylthio)-1,2,4-triazin-5(4H)-one and 5-benzyl-1,3,4-thiadiazol-2-amine and primary amine were synthesized and evaluated for their in vitro antimicrobial activity against Gram positive and Gram negative strains using a micro dilution procedure. Synthesized compounds P1BF to P15BF prove to be effective with MIC ( g/mL), among them P2BF, P6BF, P15BF showed excellent activity against a panel of microorganisms. The newly synthesized compounds were characterized using IR, 1H-NMR, 13CNMR, MASS Analysis.

Keywords: Cyanuric chloride; 4-amino-6-(tert-butyl)-3 (methylthio)-1; 2; 4-triazin-5(4H)-one 5-benzyl-1; 3; 4 -thiadiazol-2-amine; Primary amine; Antimicrobial activity. (search for similar items in EconPapers)
Date: 2017
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