Effect of Irvingia gabonensis Stem Bark on Liver Function in Sodium Arsenite-Exposed Wistar Rats

Efosa Godwin Ewere (), Ngozi Paulinus Okolie (), Gerald Ikechi Eze () and Samson Adewale Oyebadejo ()

Journal of Asian Scientific Research, 2019, vol. 9, issue 8, 81-94

Abstract: Arsenic is a known environmental pollutant that is detrimental to health. In this study, the effect of ethanol stem bark extract of Irvingia gabonensis (ESEIG) against sodium arsenite-induced hepatotoxicity in Wistar rats was investigated. Wistar albino rats of weights between 100 and 179g were assigned to eleven (11) groups of five (5) animals each. Group 1 (control) was given feed and water ad libitum. Group 2 was exposed to sodium arsenite (SA) at a dose of 4.1 mg/kg body weight (kgbw) for two weeks. Groups 3-11 were treated with ESEIG with or without SA. Treatment was done orally and lasted 28 days. Serum activities of AST, ALT, ALP, GGT as well as total bilirubin, (TBIL) and direct bilirubin, (DBIL) concentrations were assayed in serum in addition to histological assessment of liver tissues. Exposure to SA caused significant (p˂0.05) increases in all assayed parameters as well as histological anomalies such as vascular congestion and ulceration, infiltration of inflammatory cells and Kupffer cell activation when compared with control. However, treatment with ESEIG both simultaneously and 2 weeks after SA exposure, reversed the deleterious effects of SA. Paradoxically, administration of the ESEIG alone at different doses produced significant (p˂0.05) increases in all assayed parameters when compared with control except TBIL. The results obtained in this study suggest that ESEIG may be protective against SA-induced hepatotoxicity in Wistar rats and slightly toxic when administered alone, necessitating further studies.

Keywords: Arsenic; sodium arsenite; Irvingia gabonensis; Hepatotoxicity; Environmental pollutant; Medicinal plants; Bush mango; Histology. (search for similar items in EconPapers)
Date: 2019
References: Add references at CitEc
Citations:

Downloads: (external link)
https://archive.aessweb.com/index.php/5003/article/view/3917/6168 (application/pdf)
https://archive.aessweb.com/index.php/5003/article/view/3917/6551 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:asi:joasrj:v:9:y:2019:i:8:p:81-94:id:3917

Access Statistics for this article

More articles in Journal of Asian Scientific Research from Asian Economic and Social Society
Bibliographic data for series maintained by Robert Allen ().