Investigating the Protective Effects of Mentha Piperita Leaf Extract on Mercury-Chloride Induced Cardiorenal Toxicity in Adult Male Wistar Rats

Ogbuokiri Doris Kasarachi, Ugwuta Ifeoma Anastesia, Okafor Simeon Chiemelie, Obiesie Ifechukwu Justicia, Ezeokafor Emmanuel Nonso, Ejiogu Ikedichukwu Chibueze, Afuberoh Francis Chukwudi, Amasi Mitchell Onyinyechukwu and Anyiam Kennedy Ekenedirichukwu
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Ogbuokiri Doris Kasarachi: Faculty of Basic Medical Sciences, Department of Anatomy, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
Ugwuta Ifeoma Anastesia: Faculty of Basic Medical Sciences, Department of Anatomy, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
Okafor Simeon Chiemelie: Faculty of Basic Medical Sciences, Department of Anatomy, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
Obiesie Ifechukwu Justicia: Faculty of Basic Medical Sciences, Department of Anatomy, Nnamdi Azikiwe University, Nnewi Campus, Nigeria.
Ezeokafor Emmanuel Nonso: Faculty of Basic Medical Sciences, Department of Human Physiology, Nnamdi Azikiwe University, Nnewi Campus.
Ejiogu Ikedichukwu Chibueze: Dept.of Human Biochemistry, Nnamdi Azikiwe University, Nnewi Campus.
Afuberoh Francis Chukwudi: Faculty of Basic Medical Sciences, Department of Physiology, Nnamdi Azikiwe University, Nnewi Campus.
Amasi Mitchell Onyinyechukwu: Dept.of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus.
Anyiam Kennedy Ekenedirichukwu: Department of Human Anatomy, Faculty of Basic Medical Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli Campus.

International Journal of Research and Innovation in Social Science, 2025, vol. 9, issue 3s, 1251-1257

Abstract: Mercury, a potent environmental toxin, poses significant health risks to humans and animals, making it a major global health concern. This study investigates the potential protective effects of Mentha piperita (peppermint) ethanoic leaf extract on the heart of adult male Wistar rats exposed to Mercury Chloride. Thirty-five adult male rats were divided into seven groups, receiving varying doses of Mercury Chloride (5mg/kg and 0.5mg/kg) and M. piperita extract (800mg/kg and 1600mg/kg), alone or in combination, over a 4-week period after a 3-week acclimatization phase. The experiment aimed to assess changes in body weight, relative heart weight, and heart muscle integrity. Results revealed that exposure to Mercury Chloride induced weight loss in rats, with significant decreases observed in Group B (low-dose Mercury). The administration of M. piperita extract did not significantly affect body weight. Regarding heart weight, no significant differences were found between the groups, though Mercury exposure showed some alterations in cardiac function. The biochemical analysis indicated an increase in the cardiac marker CREATINE KINASE-MB in groups receiving M. piperita extract in combination with Mercury, particularly in Groups G and H, which showed significant elevation compared to the control group. There was an increase in the urea level in each group which were not statistically significant. Histological examination revealed normal cardiac myocyte arrangement in all groups. These findings suggest that M.piperita extract may offer partial protection against the cardiovascular effects of Mercury exposure and a significant protective effect on the morphology and functions of kidney, further research is needed to elucidate its mechanisms of action.

Date: 2025
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