Regulation of Gene Expression and Its Role in Development and Disease: A Case of India

Rachel Amaira ()

International Journal of Biology, 2024, vol. 4, issue 1, 46 - 56

Abstract: Purpose: The aim of the study was to investigate the Regulation of Gene Expression and Its Role in Development and Disease: A Case of India. Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries. Findings: The study revealed that regulation of gene expression plays a fundamental role in orchestrating the intricate processes of development and maintaining cellular homeostasis in health and disease. Through a myriad of molecular mechanisms, including epigenetic modifications, transcriptional regulation, and non-coding RNA activity, cells finely tune gene expression patterns to drive differentiation, tissue-specific functions, and response to environmental cues. Transcriptional regulatory networks govern the activation or repression of gene expression programs critical for organogenesis, tissue regeneration, and immune responses. Dysregulation of these networks, often involving aberrant transcription factor activity or disrupted signaling pathways, can lead to developmental abnormalities, cardiovascular diseases, and immune-related disorders. Unique Contribution to Theory, Practice and Policy: Central dogma of molecular biology & gene regulatory network theory may be used to anchor future studies on regulation of gene expression and its role in development and disease. Utilize molecular profiling technologies to stratify patients based on their gene expression profiles, enabling personalized diagnosis, prognosis, and treatment selection tailored to individual molecular signatures. Identify novel therapeutic targets by targeting dysregulated gene expression pathways in disease. Implement policies to promote data sharing and collaboration across research institutions and international consortia. Develop ethical guidelines for the use of gene expression data in research and clinical settings. Ensure responsible data stewardship, patient privacy protection, and equitable access to emerging technologies to prevent misuse and address societal concerns surrounding genomic information.

Keywords: Regulation; Expression; Role; Development; Disease (search for similar items in EconPapers)
Date: 2024
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