Comparative Characteristics of Changes in Neuron Organelles During Two-Stage Ligation of the Common Carotid Arteries in Phylogenetically Different Sections of the Brain Cortex of Outbreed White Rats

Elizaveta Bon, Natalia Maksimovich, Sergei Zimatkin, Oksana Ostrovskaya and Nikita Kokhan
Additional contact information
Elizaveta Bon: Grodno State Medical University, Grodno, Republic of Belarus
Natalia Maksimovich: Grodno State Medical University, Grodno, Republic of Belarus
Sergei Zimatkin: Grodno State Medical University, Grodno, Republic of Belarus
Oksana Ostrovskaya: Grodno State Medical University, Grodno, Republic of Belarus
Nikita Kokhan: Grodno State Medical University, Grodno, Republic of Belarus

Journal of Innovations in Medical Research, 2023, vol. 2, issue 4, 34-40

Abstract: Ultrastructural characteristics of changes in neuronal organelles during two-stage ligation of the common carotid arteries in phylogenetically different sections are important indicators of the degree of brain damage during ischemic exposure, which necessitates the study of this aspect. Two-stage subtotal cerebral ischemia was performed on 24 outbred male rats by sequential ligation of both common carotid arteries with an interval of 7 days, 3 days and 1 day. This method of modeling subtotal ischemia makes it possible to study the dynamics of the consequences of severe cerebral ischemia and the pathogenesis of ischemic brain damage. Thus, compensatory changes in neuronal organelles during two-stage ligation of the common carotid arteries included expansion of the cisternae of the Golgi complex and hyperplasia of the endoplasmic reticulum, as a reflection of the activation of compensation mechanisms during hypoxia.

Keywords: rat; cerebral ischemia; hippocampus; parietal cortex (search for similar items in EconPapers)
Date: 2023
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.paradigmpress.org/jimr/article/view/579/495 (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bdz:joimer:v:2:y:2023:i:4:p:34-40

DOI: 10.56397/JIMR/2023.04.07

Access Statistics for this article

More articles in Journal of Innovations in Medical Research from Paradigm Academic Press
Bibliographic data for series maintained by Editorial Office ().