Mean Platelet Volume and Cancer-Associated Deep Vein Thrombosis

A. Guiga, M. Krifa, A. Amara, M. Thabet, W. BenYahia, A. Atig, C. Zedini and N. Ghannouchi
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A. Guiga: Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
M. Krifa: Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
A. Amara: Department of Family and Community Medicine, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
M. Thabet: Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
W. BenYahia: Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
A. Atig: Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
C. Zedini: Department of Family and Community Medicine, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
N. Ghannouchi: Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia

Journal of Innovations in Medical Research, 2025, vol. 4, issue 2, 26-28

Abstract: Background: Deep vein thrombosis (DVT) is a common and serious complication in cancer patients, primarily driven by malignancy-induced hypercoagulability and systemic inflammation. Mean platelet volume (MPV), a hematological parameter reflecting platelet activation and inflammatory status, has been proposed as a potential marker for thromboembolic risk stratification in oncology. Objective: This retrospective study aimed to assess the association between MPV and DVT in patients with underlying cancer. Methods: We analyzed MPV levels in a cohort of 102 patients diagnosed with DVT, including 18 individuals with active malignancy. Results: Although MPV values were slightly elevated in cancer patients compared to non-cancer patients, the difference did not reach statistical significance (p = 0.86). Conclusion: Our findings suggest that MPV is not a reliable biomarker for cancer-associated DVT. Further studies exploring alternative hematological and inflammatory markers are warranted to improve risk assessment in this high-risk population.

Keywords: mean platelet volume; deep vein thrombosis; cancer; biomarkers; thrombosis; inflammation (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:bdz:joimer:v:4:y:2025:i:2:p:26-28

DOI: 10.63593/JIMR.2788-7022.2025.04.004

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