The Risk Assessment for Malignant Conversion of Cervical Pre-Neoplastic and Other Lesions by High Risk HPV and Relevant Markers

Dipanwita Ghosh, Avirup Roy and Asoke K. Roy
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Dipanwita Ghosh: Ex. Senior Research Fellow, Department of Pathology and Cancer Screening, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India
Avirup Roy: Ex House Physician, Institute of Medicine and Sagar Dutta Hospital, Kolkata, West Bengal, India
Asoke K. Roy: Ex Head Dept. of Pathology and Cancer Screening, Chittaranjan National Cancer Institute, Kolkata, West Bengal, India

Journal of Innovations in Medical Research, 2025, vol. 4, issue 3, 46-63

Abstract: Objective is to identify high risk cases of cervical pre -neoplastic lesions through the study of p16 (HR-HPV), Ki-67, DNA ploidy & Apoptosis. Western Blot analysis was performed to identify the high-risk HPV association. Immunohistochemistry was done to study Ki-67; DNA content study was performed with the help of FACS & Apoptotic index was studied by Tunnel Assay. The association of p16 with the cervical pre-neoplastic pathology was not only strong but also very significant. In this study, 72% cases were positive, and 28% cases were negative for p16 study by Western Blot analysis. Only 2 cases of other associated conditions (Koilocytosis) showed positivity for p16. The study of Ki-67 was also highly significant & showed positivity in 73% cases and has similarity with other studies. The test of proportion showed that patients with positive TUNEL assay (63%) were significantly higher than patients with negative TUNEL assay (37%) (p

Keywords: HR-HPV; pre-neoplastic lesion; cervical cancer; Western Blot; immunohistochemistry; DNA ploidy; Tunnel assay (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:bdz:joimer:v:4:y:2025:i:3:p:46-63

DOI: 10.63593/JIMR.2788-7022.2025.06.005

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