Oxidative Stress and Renal Dysfunction in Lincomycin-Induced Nephrotoxicity: Evaluating the Therapeutic Potential of Activated Charcoal

Sarah Ebutte, Gabriel Idoko, Vershima Kiekwe, Peter Onoja, Paul Beega, Thaedeus Aende, Moses Mlumun, Gabriel Akunna and Linus Saalu
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Sarah Ebutte: Department of Anatomy, College of Health Sciences, Benue State University, Makurdi, Nigeria
Gabriel Idoko: Department of Anatomy, College of Health Sciences, Benue State University, Makurdi, Nigeria
Vershima Kiekwe: Department of Anatomy, College of Health Sciences, Benue State University, Makurdi, Nigeria
Peter Onoja: Department of Anatomy, College of Health Sciences, Benue State University, Makurdi, Nigeria
Paul Beega: Department of Anatomy, College of Health Sciences, Benue State University, Makurdi, Nigeria
Thaedeus Aende: Department of Anatomy, College of Health Sciences, Benue State University, Makurdi, Nigeria
Moses Mlumun: Department of Anatomy, College of Health Sciences, Benue State University, Makurdi, Nigeria
Gabriel Akunna: Department of Anatomy, College of Health Sciences, Benue State University, Makurdi, Nigeria
Linus Saalu: Department of Anatomy, College of Health Sciences, Benue State University, Makurdi, Nigeria

Journal of Innovations in Medical Research, 2025, vol. 4, issue 4, 1-12

Abstract: Background: The kidneys play a vital role in homeostasis and metabolic waste elimination, but they are highly susceptible to toxic insults due to their role in drug metabolism. Lincomycin, a lincosamide antibiotic, has been implicated in nephrotoxicity through oxidative stress-mediated mechanisms, leading to renal dysfunction. Activated charcoal, a widely used adsorbent, has shown potential in mitigating renal damage by adsorbing toxins and modulating oxidative stress. However, its efficacy in lincomycin-induced nephrotoxicity remains poorly understood. Aim: This study investigates the protective potential of activated charcoal against lincomycin-induced nephrotoxicity by assessing oxidative stress markers, renal function indices, and histopathological changes. Methodology: Twenty-five (25) Wistar rats were divided into five groups (n=5). Group I (Control) received normal saline, while Group II received lincomycin (200 mg/kg). Groups III, IV, and V were co-administered lincomycin with varying percentages of activated charcoal (25%, 50%, and 75%). Kidney function markers (creatinine, urea), oxidative stress indices (Superoxide Dismutase [SOD], Malondialdehyde [MDA]), and histopathological changes were evaluated. Results: Lincomycin administration significantly reduced creatinine (0.59±0.07 mg/dl) and urea (19.85±2.11 mg/dl) compared to controls (0.85±0.04 mg/dl, 25.78±1.19 mg/dl; P

Keywords: nephrotoxicity; lincomycin; activated charcoal; oxidative stress; renal dysfunction; antioxidant therapy (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:bdz:joimer:v:4:y:2025:i:4:p:1-12

DOI: 10.63593/JIMR.2788-7022.2025.08.001

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