A Comprehensive Review and Evaluation of Duchenne Muscular Dystrophy (DMD) in a Specific Medical Center: Neurological and Cardiac Implications with a Focus on Retrospective Analysis of 16 Cases

Amal AlQassmi () and Huda Khaleel ()

European Journal of Health Sciences, 2024, vol. 8, issue 5, 52 - 92

Abstract: Purpose: The study aimed to investigate the effectiveness of various diagnostic and treatment strategies for Duchenne Muscular Dystrophy (DMD) in a cohort of 16 patients, focusing on their long-term outcomes. Material and Methods: A retrospective analysis was conducted using SPSS tools, including descriptive statistics, correlation analysis, and regression analysis. The study explored the relationship between initial diagnostic findings (CK levels, genetic mutations, ECHO, ECG) and patient outcomes, such as mobility and cardiac health. Findings: The study's findings revealed significant outcomes in the management of Duchenne Muscular Dystrophy (DMD). Notably, 85% of patients treated with corticosteroids experienced a 60% improvement in mobility, while 50% of those receiving physiotherapy were able to maintain ambulation. Regarding cardiac health, the mean age of onset for cardiomyopathy was 12.5 years, with a prevalence rate of 25%, which is lower than in previous studies, suggesting that earlier and more effective interventions were implemented in this cohort. Additionally, the study found that higher CK levels and specific genetic mutations were predictive of more severe disease progression. A comparative analysis with prior research indicated lower rates of wheelchair dependency and cardiomyopathy in this cohort, potentially due to differences in patient demographics and treatment protocols. Implications to Theory, Practice and Policy: This study supports the use of a multidisciplinary approach in DMD management, incorporating early diagnosis, personalized treatment plans, and innovative therapies such as plasmapheresis and gene therapy. It contributes new insights into optimizing care strategies for DMD and underscores the need for further research to validate these findings and explore new treatment avenues.

Date: 2024
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