LIPID PEROXIDATION AND EXPRESSION OF PARAOXONASE-1 (PON-1) GENE IN PATIENTS WITH PREECLAMPSIA

B. O. Arobasalu () and I. Akinlua ()

International Journal of Health Sciences, 2022, vol. 5, issue 1, 8 - 16

Abstract: Purpose: To evaluate lipid peroxidation and expression of paraoxonase-1 (pon-1) gene in patients with preeclampsia. Methodology: The study comprised of 160 participants, in which 80 were normotensive pregnant women (Group A) and 80 were preeclamptic pregnant women (Group B). Serum MDA levels and PON-1 gene activity were estimated. The expression of data was subjected to statistical analysis using SPSS version 20.0. One-way analysis of variance (ANOVA) was used to compare the test samples, p value <0.05 was considered significant. Findings: MDA levels were significantly elevated in preeclamptic pregnant women when compared to normotensive. Also, PON-1 gene expression levels were significantly decreased in preeclamptic pregnant women when compared to normotensive. Unique contribution to theory, practice and policy: The significant increase in the plasma level of Malondialdehyde and decreases expression of PON-1 gene could be responsible for the presence of oxidative stress and its associated complications in PE patients.

Keywords: Preeclampsia; Lipid Peroxidation; Paraoxonase-1 Oxidative Stress; Malondialdehyde (search for similar items in EconPapers)
Date: 2022
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Persistent link: https://EconPapers.repec.org/RePEc:bhx:ojijhs:v:5:y:2022:i:1:p:8-16:id:830

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