The Effect of Ethanolic Soursop Leaf Extract on Caffeine-Induced Anxiety in Female Wistar Rats

Ezeokafor Emmanuel Nonso, Nnaemeka Wuraola Serah, Njidea Constance Uchefuna, Nwanaga Clinton Uche, Nsofor Cordelia U., Aralu Obed Chinwendu, Afuberoh Francis Chukwudi and Ugochukwu Precious Chisom
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Ezeokafor Emmanuel Nonso: Department of Human Physiology, Faculty of Basic Medical Science, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus.
Nnaemeka Wuraola Serah: Human Biochemistry, Nnamdi Azikiwe University
Njidea Constance Uchefuna: Department of Paediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi (NAUTH).
Nwanaga Clinton Uche: Dept.of Human Physiology, University of Portharcourt.
Nsofor Cordelia U.: Department of Human Physiology, Nnamdi Azikiwe University, Nnewi Campus
Aralu Obed Chinwendu: Dept of Human Physiology, Faculty of Basic Medical Science, Abia state uturu.
Afuberoh Francis Chukwudi: Dept.of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi campus.
Ugochukwu Precious Chisom: Department of Human Physiology, Nnamdi Azikiwe University, College of Health sciences.

International Journal of Research and Scientific Innovation, 2024, vol. 11, issue 12, 195-204

Abstract: Soursop is a tropical fruit tree that has gained attention for its potential health benefits, which are attributed to its rich phytochemical composition, including flavonoids. The present study investigates the effects of ethanolic extracts of soursop (Annona muricata) leaves on caffeine-induced anxiety in female Wistar rats. Caffeine, a widely consumed psychoactive stimulant, is known to induce anxiety-like behaviors, which can negatively impact overall well-being (Hughes & Hancock, 2017). The anxiolytic potential of soursop leaves, traditionally used in herbal medicine, is explored in this context due to their reported calming properties and ability to modulate neurotransmitter levels (Akomolafe et al., 2015). In this study, female Wistar rats were administered caffeine to induce anxiety, followed by treatment with varying doses of ethanolic soursop leaf extract. Behavioral assessments were conducted using the elevated plus maze and open field tests to evaluate anxiety levels. Preliminary results indicate that the ethanolic extract significantly reduced anxiety-like behaviors in caffeine-treated rats, suggesting a protective effect against caffeine-induced anxiety. These findings support the potential use of soursop leaf extract as a natural anxiolytic agent and highlight the importance of dietary choices in managing anxiety disorders.

Date: 2024
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