Association of Cytokine Gene Polymorphism with Susceptibility of Ankylosing Spondylitis

Raisa Enayet Badhan, Ahmed Abu Saleh Shaheda Anwar, Shaila Akhtar, Taskin Jahan and Md. Jahangir Alam
Additional contact information
Raisa Enayet Badhan: Medical officer (Microbiology), Sheikh Hasina National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh.
Ahmed Abu Saleh Shaheda Anwar: Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.
Shaila Akhtar: Lecturer, Department of Microbiology, Green Life Medical College, Dhaka, Bangladesh.
Taskin Jahan: Lecturer (Department of Microbiology), Chattagram International Medical College and Hospital, Chattagram, Bangladesh
Md. Jahangir Alam: Resident (Department of Ophthalmology), Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

International Journal of Research and Scientific Innovation, 2024, vol. 11, issue 1, 108-114

Abstract: This article reviews various studies on cytokine polymorphism in ankylosing spondylitis and looks for the associations between the susceptibility to disease. To find the pertinent research, a thorough search of the literature was undertaken. Articles were chosen for this review should be met some criteria: Studies should be case control studies, should described the association between the cytokine gene polymorphism (IL-1R2, IL-12B, IL-10, TNF-α and IL-23R) with the pathogenesis of AS, frequencies of genotypes and alleles in case and control groups could be collected. This article reviewed 20 different studies on Cytokine gene polymorphisms. Nine single-nucleotide polymorphisms (SNPs) of IL-23R (rs11209026, rs1004819, rs10489629, rs11465804, rs1343151, rs11209032, rs1495965, rs7517847, rs2201841) are linked to AS susceptibility out of the seventeen SNPs. Additionally, based on ethnicity revealed a noteworthy association between seven IL-23R SNPs and AS susceptibility in Americans and Europeans, but not in Asian population. Furthermore, susceptibility to AS is also conferred by the IL-10–819 C/T, IL-10-1082A/G, G/G genotype and TNF-α−857 C/T polymorphisms, particularly in Asian populations. IL- 1R2 in rs 2310173 polymorphism found to be associated with AS in European, not in Asian.

Date: 2024
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.rsisinternational.org/journals/ijrsi/d ... -issue-1/108-114.pdf (application/pdf)
https://rsisinternational.org/journals/ijrsi/artic ... ylosing-spondylitis/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bjc:journl:v:11:y:2024:i:1:p:108-114

Access Statistics for this article

International Journal of Research and Scientific Innovation is currently edited by Dr. Renu Malsaria

More articles in International Journal of Research and Scientific Innovation from International Journal of Research and Scientific Innovation (IJRSI)
Bibliographic data for series maintained by Dr. Renu Malsaria ().