Investigation of the Subchronic Toxicity of Graded Doses of Extracts of Dialium guineense Stem Bark in Rats

Abu O.D.,Awhin, E.P Enadeghe, R and O.P. Eze-Nwaobasi
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Abu O.D.,Awhin, E.P Enadeghe, R: Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria.
O.P. Eze-Nwaobasi: Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Delta State University, Abraka, Delta State, Nigeria

International Journal of Research and Scientific Innovation, 2024, vol. 11, issue 1, 15-23

Abstract: Aim: To investigate the subchronic toxicity of graded doses of aqueous and ethanol extracts of D. guineense stem bark in rats. Materials and Methods: A total of seventy (70) rats (35 per extract) weighing 160 to 180 g (mean weight = 170 ± 10 g) were divided into seven (7) groups of five (5) rats each. Group I served as control, while rats in groups II – VII received graded doses of extract (200 – 5000 mg/kg body weight, bwt) for a duration of 28 days. Weight parameters, liver malondialdehyde (MDA) level and histopathological assessment were carried out. Results: Percentage increases in body weights of rats treated with aqueous or ethanol extract of D. guineense stem bark were significantly reduced, when compared with control group (p 0.05). Similarly, the extracts did not significantly alter the normal architecture of the liver, but induced mild periportal lymphocytosis and kupffer cell activation. Conclusion: The aqueous and ethanol extracts of the medicinal plant stem bark did not elicit any deleterious effects on rat liver.

Date: 2024
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