Amino Acid Profile, Total Protein and Histological Changes in Female Wistar Rats After Administration of Dichloromethane Extract of Heterotis Rotundifolia Leaves on Dermal Wound

Ogechukwu E. Ezim and Jane A. Agwu
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Ogechukwu E. Ezim: Department of Biochemistry, Faculty of Science, University of Port Harcourt, Choba, Rivers State, Nigeria
Jane A. Agwu: Department of Biochemistry, Faculty of Science, University of Port Harcourt, Choba, Rivers State, Nigeria

International Journal of Research and Scientific Innovation, 2024, vol. 11, issue 2, 215-223

Abstract: The study investigated the amino acid and wound healing potentials of the leaves of Heterotis rotundifolia. Amino acid analysis was performed using HPLC. Total protein level, body weight and histology were studied. Excision wound(2cm) was induced on the dorsal skin of 75 wistar rats (176-308g) divided into five groups of fifteen animals: control, 0.1g Vaseline, 0.1g gentamicin (reference drug), 0.1g extract+0.1g Vaseline (HRE1) and 0.2g extract+0.1g Vaseline (HRE2). At the end of days 1, 7, 14 and 21, rats were sacrificed and blood was collected for wound healing parameters while wound surface was taken for histology. The result revealed a higher total protein level of HRE1 with a significant difference (p

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:bjc:journl:v:11:y:2024:i:2:p:215-223

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