Evaluation Of Python Fat-Based Topical Formulation For Enhanced Furuncles (Boils) Management

Ordu J I and Amajuo N F
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Ordu J I: Department of Pharmaceutics and Pharmaceutical Technology Faculty of Pharmaceutical Sciences, University of Port Harcourt
Amajuo N F: Department of Pharmaceutics and Pharmaceutical Technology Faculty of Pharmaceutical Sciences, University of Port Harcourt

International Journal of Research and Scientific Innovation, 2024, vol. 11, issue 2, 283-294

Abstract: Boils are common skin infections that can be painful and unsightly and contemporary treatments for it involves, use of oral and topical antibiotics, incision and drainage. In this study, Python fat-based topical formulation was made and evaluated for its efficacy, stability and general properties in the treatment and management of boils for a period of time. The study dwelt on formulation of four batches of creams comprising of, the control (C1) without raw material (python fat), the standard containing Gentamicin only (C2), (C3) formulated product with python fat and C4 (the raw python fat alone). Randomized study was conducted with involvement of twelve wistar rats where three rats were apportioned to each batch. Induction of furuncles was carried out after shaving a section of the skin around the thigh using a shaving cream then with aid of syringe, 0.1ml of isolated S. aureus isolate was injected through a hair pore. The animals were left for 4days to allow for prominent growth of boils and the level of indurations measured. Upon successful induction of boils, animals in various groups were treated accordingly using the cream from each batch every 12 hours for 9 days and then monitored for reduction in the diameter of the growth. The formulated products reduced the diameter of the boil faster and the median time for complete healing was shorter with results almost same in group treated with batches of C2, C3, and C4 than in C1. The formulated cream was found to be washable, non irritant, light brown in color, pleasing odor with srpeadability of 6.7gm.cm/sec. Stability studies for a three weeks duration under varied storage conditions (5 and 25°C) show the product stored at 5°C to maintain a mean pH of 5.42 and viscosity of 5811cp while that at 25OC, the mean pH was 5.37 with viscosity of 5716cp. The python fat-based topical formulation is a safe and effective treatment for boils however; its stability at room temperature is still an issue of concern

Date: 2024
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