Evaluation of Creatine Kinase-MB Activity and Cortisol Level in Hypertensive Mycobacterium Tuberculosis Patients Receiving Treatment in Nnewi

Ihim Ac, Ifebude Eo, Onyenekwe Cc, N Osakue, Awalu Jc and Ikwelle Ta
Additional contact information
Ihim Ac: Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Ifebude Eo: Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Onyenekwe Cc: Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
N Osakue: Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Awalu Jc: Department of Medical Laboratory Science, Evangel Akaeze Ebonyi State, Nigeria
Ikwelle Ta: Department of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.

International Journal of Research and Scientific Innovation, 2024, vol. 11, issue 4, 784-793

Abstract: Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), imposes a health challenge globally. Tuberculosis is an infectious disease that most often affects the lungs, and it spreads through the air when infected people cough, sneeze, or spit. This study was aimed at evaluating creatine kinase-MB (CK-MB) activity and cortisol levels in Mycobacterium tuberculosis patients receiving therapy at Nnewi. A cross-sectional study involved 90 participants consisting of 45 TB+ individuals and 45 healthy controls. A questionnaire was used to obtain the age, sex, and other vital information needed for the study. The body mass index (BMI) of the participants was calculated. Their systolic and diastolic blood pressure was obtained using an Accu-Answer automatic blood pressure monitor. Ziehl-Nelseen (ZN) sputum smear microscopy determined Mycobacterium tuberculosis infection and confirmed positive using GeneXpert. Plasma cortisol level was determined using an Enzyme-linked immunosorbent assay whereas plasma CK-MB activity was determined spectrophotometrically. Independent t-test and Pearson`s correlation coefficient were used for statistical analysis. Significant levels were considered at p 0.05). There was a moderate positive correlation between systolic blood pressure (SBP) and DBP (r = 0.50; p = 0.01) in the test group and a strong positive correlation between SBP and DBP in the control. SBP and cortisol showed a moderate positive correlation with DBP and cortisol in the test group. In conclusion, there was no predisposition to acute myocardial infarction and inflammation in the subjects studied.

Date: 2024
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.rsisinternational.org/journals/ijrsi/d ... -issue-4/784-793.pdf (application/pdf)
https://rsisinternational.org/journals/ijrsi/artic ... -treatment-in-nnewi/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bjc:journl:v:11:y:2024:i:4:p:784-793

Access Statistics for this article

International Journal of Research and Scientific Innovation is currently edited by Dr. Renu Malsaria

More articles in International Journal of Research and Scientific Innovation from International Journal of Research and Scientific Innovation (IJRSI)
Bibliographic data for series maintained by Dr. Renu Malsaria ().