Effect of Methanol Extract of A. Bonnei on Some Neuroprotective Parameters/Markers (Vitamin E, Adenine Deaminase and Acetylcholinesterase) in Wistar Rats

Aroh Samuel Chinekwu, Winnifred Njideka Adiri, Promise Udoka Asogwa, Bruno Basil, Ireh Princes Chioma and Okereke Chiamaka Edith
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Aroh Samuel Chinekwu: University of Nigeria Nsukka, Nigeria
Winnifred Njideka Adiri: University of Nigeria Nsukka, Nigeria
Promise Udoka Asogwa: University of Nigeria Nsukka, Nigeria
Bruno Basil: University of Nigeria Nsukka, Nigeria
Ireh Princes Chioma: University of Nigeria Nsukka, Nigeria
Okereke Chiamaka Edith: University of Nigeria Nsukka, Nigeria

International Journal of Research and Scientific Innovation, 2024, vol. 11, issue 7, 1105-1127

Abstract: The aim of this work is to evaluate the effect of methanol extract of A. bonnei on some neuroprotective parameters/markers (vitamin E, adenine deaminase and acetylcholinesterase) in Wistar Rats. The leaves of the plant A. bonnei were collected at Diogbe, Igbo-Etiti local government area of Abia state. They were air dried, milled and stored in an air tight container for further use. A total of 16 adult Wistar rats of male sex (100–130 g) used for this study were acclimatized for one week and the rats were randomly divided into four equal groups. Group 1 (normal control) received only water and feed. Group 2 served as the positive control (and received mercury chloride). Group 3 was intoxicated with mercury chloride and treated with Diazepam (5 mg/kg). Animals in group 4 were neurointoxicated and treated with the plant extract (400 mg/k). From the results of vitamin E, in the cerebellum, it was observed group 3 when compared to the group 1, showed a significant (p 0.05) on comparism with group 1. Furthermore, the group 2 on comparism to the group 3, indicated a significant decrease (p 0.05) decrease. Furthermore, when the untreated group was compared to the intoxicant + standard drug group, a significant (p 0.05) increase. Considering the cerebrum, the untreated group when compared to the normal control, showed a significant (p 0.05) decrease existed when the untreated group was compared with the normal control; also the intoxicant + extract group showed an insignificant (p>0.05) decrease on comparism to the normal control. Furthermore, an insignificant (p>0.05) decrease was shown when the untreated group was compared to the intoxicant + standard drug group; while an insignificant (p 0.05) decrease was shown when the untreated group was compared with the normal control; while a significant (p 0.05) decrease was recorded when the untreated was compared to the intoxicant + standard drug group; while a significant increase (p

Date: 2024
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