Vitamin D Co-Supplementation Against Methamphetamine-Induced Nephrotoxicity in Wistar Rats

Okafor Emeka Christian, Ezeokafor Emmanuel Nonso, Nnaemeka Wuraola Serah, fegwu Njoku Orji, Ajaegbu Obinna Chinedu and Nwozor Adaeze Divine
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Okafor Emeka Christian: Faculty of Basic Medical Sciences, Department of Human Anatomy, Nnamdi Azikiwe University, Nnewi Campus.
Ezeokafor Emmanuel Nonso: Faculty of Basic Medical Sciences, Department of Human Physiology, Nnamdi Azikiwe University, Nnewi Campus.
Nnaemeka Wuraola Serah: Faculty of Basic Medical Sciences, Department of Human Biochemistry, Nnamdi Azikiwe University, Nnewi Campus.
fegwu Njoku Orji: Faculty of Basic Medical Sciences, Department of Human Anatomy, College of Medicine and Health Sciences, Abia State University.
Ajaegbu Obinna Chinedu: Faculty of Basic Clinical Medicine, Department of Pharmacology and Therapeutics, Nnamdi Azikiwe University.
Nwozor Adaeze Divine: Faculty of Basic Medical Sciences, Department of Human Physiology, Nnamdi Azikiwe University, Nnewi Campus.

International Journal of Research and Scientific Innovation, 2025, vol. 12, issue 15, 1197-1203

Abstract: Methamphetamine (METH) is a white, odorless, bitter-tasting crystalline psycho-stimulant drug related to amphetamine. It is highly addictive and often employed for the potent euphoric effects it produces, similar to cocaine. Vitamin B complex and vitamin D are noted for their potential protective effects against kidney damage. This study is aimed at investigating the effect of co-administration of vitamin B complex and vitamin D on the kidney in methamphetamine-induced nephrotoxicity in adult male Wistar rats. A total of twenty-four (24) adult male Wistar rats weighing 120–140g were grouped into six groups of n=4 each, labeled A to F. Group A served as the control (feed and water only), group B received 10 mg/kg of methamphetamine only, group C received 100 mg/kg of vitamin B complex, group D received 20 mg/kg of vitamin D, group E received 10 mg/kg of methamphetamine and 100 mg/kg of vitamin B complex, while group F received 10 mg/kg of methamphetamine and 20 mg/kg of vitamin D. All substances were administered orally for the duration of twenty-one (21) days. The results showed a statistically significant decrease in total body weight in group B (P 0.05) when compared to A. The result on urea and creatinine levels are indicated respectively, a 37.99% and 40% significant increase in group B (P 0.05), and a slight 5.8% and 7.67% non-significant increase in groups E and F (P>0.05) when compared to A.

Date: 2025
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