Evaluation of Wound Healing Potential of Ethanol-Seed Extract of Chrysophyllum albidum in Wistar Rat

R. D. Oladeji, Opoola J. A. and Adeyanju S. T.
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R. D. Oladeji: Chemistry Department, Federal College of Education (Special), Oyo, Nigeria
Opoola J. A.: Biology Department, Federal College of Education (Special), Oyo, Nigeria
Adeyanju S. T.: Integrated Science Department, Federal College of Education (Special), Oyo, Nigeria

International Journal of Research and Scientific Innovation, 2025, vol. 12, issue 5, 1554-1564

Abstract: Wound healing activities of the ethanol-seed extract of Chrysophyllum albidum have been established. However, scientific evaluation of its wound healing potential at different concentrations is lacking. Thus, the present study aimed to assess the wound healing activity of ethanol extract of Chrysophyllum albidum seeds at different concentrations. The seed cotyledon was extracted with ethanol by continuous cold extraction. Phytochemicals, antioxidant and antimicrobial activities of the extract were assayed by standard methods. Five groups of male wistar rats consisting of five animals each was used for the animal studies. The group 1 served as the negative control (untreated). Groups 2, 3 and 4 was treated with ethanol extract at varying dose of 2g/ml, 4g/ml and 6g/ml respectively, serving as the test groups. Group 5 animals served as the positive control (reference). All animals were experimentally wounded in the sterilized shaved dorsal fur region. Comparative wound healing efficiency of the control, test and reference groups were assessed.

Date: 2025
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