Evaluation of the Anti-Pyretic Properties of Aqueous Leaf Extract of Luffa Cylindrica in Baker’s Yeast-Induced Pyrexia in Wistar Rats

C. S. Obi, U. C. Awarajih, A. O. ThankGod and S. Inegbenehi
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C. S. Obi: Department of Science Laboratory Technology, Federal Polytechnic Ohodo, Enugu State
U. C. Awarajih: Department of Science Laboratory Technology, Federal Polytechnic Ohodo, Enugu State
A. O. ThankGod: Department of Biochemistry, University of Port Harcourt
S. Inegbenehi: Department of Biochemistry, Pamo University of Medical Science, Port Harcourt

International Journal of Research and Scientific Innovation, 2025, vol. 12, issue 7, 923-929

Abstract: Fever is a common clinical symptom of many infectious and inflammatory conditions, often managed with synthetic antipyretics that pose safety concerns in vulnerable populations. This study investigated the anti-pyretic potential of aqueous leaf extract of Luffa cylindrica using Baker’s yeast-induced pyrexia model in Wistar rats. Twenty (20) rats were divided into five groups (n=4). Group 1 animals were treated with 0.5 ml distilled water as the normal control. Group 2 were treated with 0.4% Baker’s yeast only as the negative control. Group 3 were treated with 0.4% yeast and 800 mg/kg Luffa cylindrica extract. Group 4 were treated with 0.4% yeast and 1600 mg/kg Luffa cylindrica extract. Group 5 were treated with 0.4% yeast and 500 mg/kg paracetamol considered as positive control. Increased rectal temperatures at 1, 2, 3, and 4 hours after administration of treatments in Baker’s yeast-induced pyrexia rat model was measured with thermometer. Treatment with extract doses of 800 mg/kg and 1600 mg/kg were compared to paracetamol (500 mg/kg) and a significance decrease (p

Date: 2025
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