Design, Formulation Development and Characterization of Empagliflozin Nanosuspension

S. Lidiya, U. Meenakshi, K. Mounika and J. Rajendra Kumar
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S. Lidiya: School of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Medchal-Malkajgiri, Hyderabad, Telangana – 500 088, India
U. Meenakshi: School of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Medchal-Malkajgiri, Hyderabad, Telangana – 500 088, India
K. Mounika: Department of Pharmaceutics, School of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Medchal-Malkajgiri, Hyderabad, Telangana – 500 088, India
J. Rajendra Kumar: Department of Pharmaceutics, School of Pharmacy, Anurag University, Venkatapur, Ghatkesar, Medchal-Malkajgiri, Hyderabad, Telangana – 500 088, India

International Journal of Research and Scientific Innovation, 2025, vol. 12, issue 6, 1392-1401

Abstract: To develop empaglifazon nanosuspension by Solvent evaporation technique using ethanol as organic phase then aqueous phase was prepared by dissolving acetate cellulose in water then add poloxamer-188 and sodium lauryl sulphate. Physicochemical properties like melting point, solubility, particle size and shape, in-vitro diffusion studies etc. were performed for the prepared nanosuspension formulations. Based on drug excipient compatibility studies such as FTIR images shown that there is no interaction between drug and excipients. XRD studies revealed the crystalline structure of the formulation. A surface characteristic was determined by SEM. In-vitro diffusion studies were carried out by Franz diffusion cell, found the ranges around 95% for both pure and optimized formulations. Research indicates that the Empagliflozin nanosuspension is optimal for prolonged and extended release. This nanosuspension has been found to effectively reduce diabetes mellitus when taken orally.

Date: 2025
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