Congenital Hypothyroidism with Atrial Septal Defect Accompanied and Severe Anemia in A 15-Month-Old Infant:A Case Report from A Resource Limitec Tanzanian Setting

Evelyne Modestus Banda, Korhigwa G. Mghamba, Mwijage Wenceslaus and Siya Sijabaje
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Evelyne Modestus Banda: Tanga Regional Referral Hospital-Bombo, Tanzania
Korhigwa G. Mghamba: Tanga Regional Referral Hospital-Bombo, Tanzania
Mwijage Wenceslaus: Tanga Regional Referral Hospital-Bombo, Tanzania
Siya Sijabaje: Tanga Regional Referral Hospital-Bombo, Tanzania

International Journal of Research and Scientific Innovation, 2025, vol. 12, issue 6, 236-242

Abstract: Congenital hypothyroidism (CH) is a condition characterized by the thyroid gland’s inability to synthesize sufficient quantities of thyroid hormones in neonates. These hormones are indispensable for normal cerebral development, growth, and metabolic functions in infants. Often, it constitutes a permanent condition that necessitates lifelong management. The incidence of congenital hypothyroidism is estimated to be approximately 1 in 2,000 to 4,000 live births. This condition can be classified based on its etiology into “Primary†or “Secondary†hypothyroidism, the latter also referred to as “Central†hypothyroidism, or based on its duration into “Transient,†indicating potential improvement over time, or “Permanent†hypothyroidism. The predominant congenital form of hypothyroidism is primary hypothyroidism, primarily resulting from thyroid dysgenesis, which accounts for approximately 80% of cases. Notably, the majority of infants diagnosed with CH are typically asymptomatic at birth.

Date: 2025
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