Effect of Ethanoic Leaf Extracts of Carica Papaya and New Bouldia Laevis on Lipid Profile of Diabetic Wistar Rats

Njideka Nancy Njoku-Oji, Njoku Oji Ifegwu, Marvelous Igbonaju, Ifeoma Frances Okwuonu, Chidinma Winifred Chukwukaeme, Chidinma Ifeyinwa Mmaju and Peter Osezele Okonudo
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Njideka Nancy Njoku-Oji: Department of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Njoku Oji Ifegwu: Department of Anatomy, College of Medicine and Health Sciences, Abia State University Uturu, Abia State, Nigeria
Marvelous Igbonaju: Department of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Ifeoma Frances Okwuonu: Department of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Chidinma Winifred Chukwukaeme: Department of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Chidinma Ifeyinwa Mmaju: Department of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Peter Osezele Okonudo: Department of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.

International Journal of Research and Scientific Innovation, 2022, vol. 9, issue 2, 19-25

Abstract: Objective: This study was carried out to investigate the effect of the ethanolic leaf extracts of Carica papaya (C. papaya) and Newbouldia laevis (N. laevis) on the lipid profile of alloxan-induced Wistar rats. Methodology: Forty (40) male wistar rats weighing 130-150g were procured and acclimatized for two weeks, after which they were divided into eight (8) groups of five (5) rats each, and were housed in cages. The groups were designated as groups A, B, C, D, E, F, G and H. Groups B – H were induced with diabetes using alloxan. Group A served as the control group and received only distilled water; group B diabetic received only distilled water only, while groups C – H diabetic received 400mg/kg of C. papaya, 600mg/kg of C. papaya, 400mg/kg of N. laevis, 600mg/kg of N. laevis, 200mg/kg of C. papaya + 200mg/kg of N. laevis and 300mg/kg of C. papaya + 300mg/kg of N. laevis respectively for 21 days through oral route with the aid of oral gastric tube. On the 22nd day, the animals were sacrificed by chloroform inhalation, and blood samples were obtained through cardiac puncture for lipid profile parameters’ assays. Data obtained were analyzed using SPSS version 25 and (P

Date: 2022
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