Combined Effect of Ethanolic Leaf Extracts of Carica Papaya and Newbouldia Laevis on Hematological Parameters and Sperm Quality of Alloxan-Induced Rats

Ifegwu Njoku Oji, Agbai Johnson Ukwa, Njoku-Oji Njideka Nancy, Elem Chambelin Jamike, Aligwekwe Athanasius Ugochukwu and Ohaeri Esther Adaukwu
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Ifegwu Njoku Oji: Department of Anatomy, College of Medicine and Health Sciences, Abia State University Uturu, Abia State, Nigeria.
Agbai Johnson Ukwa: Department of Anatomy, College of Medicine and Health Sciences, Abia State University Uturu, Abia State, Nigeria.
Njoku-Oji Njideka Nancy: Department of Human Physiology, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Elem Chambelin Jamike: Department of Anatomy, College of Medicine and Health Sciences, Abia State University Uturu, Abia State, Nigeria.
Aligwekwe Athanasius Ugochukwu: Department of Anatomy, Madonna University, Elele Campus, Nigeria.
Ohaeri Esther Adaukwu: Department of Biochemistry, Abia State University, Uturu, Abia State, Nigeria.

International Journal of Research and Scientific Innovation, 2022, vol. 9, issue 3, 37-46

Abstract: Objective: This study was carried out to investigate the effect of ethanolic leaf extracts of C. papaya and N. laevis on hematological parameters and sperm quality of alloxan-induced diabetic wistar rats. Methodology: Forty male rats weighing 130-180g were procured, acclimatized for two weeks, after which, were divided into eight groups of five rats each, and were housed in cages. The groups were designated as groups A – H. Group A served as the control group and received distilled water only. Groups B – H were induced with diabetes using alloxan. Group B did not receive any treatment, while the groups C – H received 400mg/kg of C. papaya leaf extract, 600mg/kg of C. papaya leaf extract, 400mg/kg of N. laevis leaf extract, 600mg/kg of N. laevis leaf extract, 200mg/kg of C. papaya + 200mg/kg of N. laevis, and 300mg/kg of C. papaya + 300mg/kg of N. laevis leaf extract respectively for 21 days orally with oral gastric tube. On the 22nd day, the animals were sacrificed via chloroform inhalation and blood samples were collected through ocular puncture for hematological analyses, and epididymis were collected for sperm quality study. All data were tabulated and statistically analyzed using SPSS version 25.0. Result: The levels of WBC, RBC, HGB, PCV, sperm motility and sperm count were significantly (P

Date: 2022
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