Evaluation of Non-Adrenergic – Non-Cholinergic Mediators in Response to Thermal Balance in Lifestyle Clients at Risk of Heat Illness

Emmanuel Kairania
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Emmanuel Kairania: Busitema University, Faculty of Health Sciences

International Journal of Research and Innovation in Applied Science, 2025, vol. 10, issue 3, 9-55

Abstract: The study examined how non-adrenergic-non- cholinergic (NANC) mediators affect the body’s temperature balance and heart rate responses in people prone to heat-related illnesses because of their lifestyle. The study aimed to investigate the influence of prostaglandins and histamines on core body temperature, skin temperature, sweat rate, heart rate, and blood pressure dynamics during exercise and heat stress, providing insights into the physiological mechanisms underlying heat regulation in at-risk populations. The research methodology involved systematically examining core body temperature, skin temperature, sweat rate, heart rate, and blood pressure changes during control, as well as prostaglandin and histamine blockade in lifestyle clients deemed vulnerable to heat illness. These disruptions in non-adrenergic and non-cholinergic pathways led to changes in cardiovascular responses. This could affect thermal balance and make people more likely to have heat-related problems. Changes in NANC mediators led to changes in core body temperature, skin temperature, sweat rate, heart rate, and blood pressure. This shows the relationship between these mediators and how the heart and lungs react to heat stress. The observed trends provide valuable implications for managing thermal balance and preventing heat-related issues in at-risk lifestyle clients. Finally, looking at the role of NANC mediators in controlling temperature gives us a better idea of how the body reacts to heat in people who are more likely to get sick. We propose personalized interventions that focus on hydration and cooling strategies, and further research into other pathways that influence thermal balance and cardiovascular responses in high-risk individuals. By integrating these findings into clinical practice, healthcare providers can enhance preventive measures and interventions for lifestyle clients at risk of heat illness, contributing to improved outcomes and well-being in heat-exposed environments. This study offers valuable insights into the interplay between NANC mediators and thermal balance, advancing our understanding of heat-related physiology and promoting optimal health in at-risk populations.

Date: 2025
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