Cellular Senescence, Aging, and Cancer: Molecular Pathways and Emerging Therapeutic Interventions

Emmanuel Olanrewaju Adebayo, Blessing Adeola Fadola, Oluwadayomi Adedeji and Imoleayo Moses Olorunyolemi
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Emmanuel Olanrewaju Adebayo: Federal University of Technology Akure, Nigeria
Blessing Adeola Fadola: Federal University of Technology Akure, Nigeria
Oluwadayomi Adedeji: Africa Research Institute of Technology Osun State, Nigeria
Imoleayo Moses Olorunyolemi: North Carolina Agricultural and Technical State University, Greensboro USA

International Journal of Research and Innovation in Applied Science, 2025, vol. 10, issue 5, 201-212

Abstract: The global biological process of aging is marked by a slow deterioration in physiological and cellular processes, which makes people more vulnerable to degenerative diseases, including cancer. Scientists are growing more interested in the molecular pathways that connect aging and carcinogenesis as life expectancy increases worldwide, and aging-related malignancies become more common. Cellular senescence, a stress-induced, irreversible growth arrest condition, is a key element of this connection. Senescent cells are initially beneficial because they stop damaged cells from proliferating, but with time, they build up and create a pro-inflammatory environment called the senescence-associated secretory phenotype (SASP), which encourages tissue malfunction and cancer in older people. According to López-Otín et al. (2013), aging is driven by nine interconnected hallmarks: genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss of proteostasis, deregulated nutrient sensing, stem cell exhaustion, cellular senescence, and altered intercellular communication. These hallmarks disrupt cellular homeostasis, fostering an environment conducive for tumor growth and development. However, over time, small interventions have emerged, resolving some of these issues, developing new avenues for solutions, or modifying the ones that already exist. This journal delves further into these aging processes, emphasizing how they contribute to the development and spread of aging related diseases with a major look at cancer. It also examines new treatments that target these pathways to postpone aging-related illnesses, such as lifestyle changes and senolytic medications which prevent senescence expression. In the end, the study promotes a multidisciplinary strategy to prolong life expectancy and lessen the impact of age-related malignancies.

Date: 2025
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