Indigenous Medicinal Plants use Sekhukhune, Limpopo, South Africa as Biofilm Inhibitors for the Mycobacterium Smegmatis

Dr. Jacobus Kori Madisha
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Dr. Jacobus Kori Madisha: Phytomedicine, Limpopo Education, 84 Limpopo Street, Modimolle, South Africa P.O Box 1777, Marble Hall 0450, South Africa

International Journal of Research and Innovation in Applied Science, 2025, vol. 10, issue 5, 517-521

Abstract: The use of ordinary products to stimulate healthiness is as ancient as human sophistication. In contemporary years, the awareness of ordinary harvests derived from plants as ample foundations of naturally active complexes has determined their utilisation near the examination for novel biochemical products that can lead to further pharmaceutical formulations. Opportunistic pathogens, escalation their virulence by acquiring resistance to orthodox antimicrobials, initiating infections, particularly in immunosuppressed hosts. Ethnobotanical information on these plants was obtained. Crude acetone extracts of 11 selected medicinal plants obtained in Sekhukhune, South Africa were screened for their ability to inhibit Mycobacterium smegmatis and a clinical strain resistant to first-line drugs and one second-line Rifampicin drug microplate assay to determine the minimum inhibitory concentration (MIC). Eleven plants were gathered and their acetone extracts evaluated for anti-mycobacterial activity by the micro-dilussion assay. All extracts were tested for both antibacterial activity and biofilm inhibitory activity. The greatest encouraging herbal abstracts in combating biofilm, particular their extraordinary capability to decrease it to small concentrations were the necessary oils removed from Schotia brachpetala(B) ,Euphorbia tirucali(L), Eucalyptus camadulensis(L), Aloe marlothii (L), Elephantorrize elephantine( R ), Peltophorum africanum(B)

Date: 2025
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