Research Article: Role of SNP in the Breast Cancer Development of Indian Women

Ashish B. Gulwe and Shriram S. Dawkhar
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Ashish B. Gulwe: School of Technology ,Dept. of Bioinformatics ,Swami Ramanand Teerth Marathwada University, Nanded, Sub campus Latur,413531 Maharashtra, India
Shriram S. Dawkhar: Sinhgad Business School,19/15, Smt Khilare Marg, Erandwane, Pune.Maharashtra-411004. India.

International Journal of Research and Innovation in Applied Science, 2025, vol. 10, issue 6, 1160-1173

Abstract: Breast cancer represents a significant public health challenge in India, with increasing incidence rates and unique genetic factors potentially contributing to disease progression. This research paper investigates the role of Single Nucleotide Polymorphisms (SNPs) in the development and progression of breast cancer among Indian women. Through a comprehensive analysis of genetic databases, clinical records, and primary survey data from 250 participants across five major metropolitan regions of India, this study identifies specific SNP markers associated with increased breast cancer risk in the Indian female population. The research found significant associations between polymorphisms in BRCA1, BRCA2, TP53, and PALB2 genes and breast cancer susceptibility, with certain SNPs showing higher prevalence in Indian populations compared to global averages. Additionally, the study established correlations between specific SNPs and clinical outcomes, treatment responses, and survival rates. These findings contribute to the growing body of knowledge regarding population-specific genetic risk factors and may inform the development of targeted screening protocols and personalized treatment approaches for breast cancer patients in India.

Date: 2025
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