The Impact of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) in Healthcare: A Narrative Review

Blessing Ifunanya Maduelosi, Dr. Janis Vella Szijj and Prof. Anthony Serracino-Inglott
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Blessing Ifunanya Maduelosi: Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
Dr. Janis Vella Szijj: Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta
Prof. Anthony Serracino-Inglott: Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, Malta

International Journal of Research and Innovation in Applied Science, 2025, vol. 10, issue 6, 1761-1772

Abstract: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) are deoxyribonucleic acid segments that can be used in gene editing to provide a defence mechanism against viral DNA in prokaryotes. Compared to other genome editing techniques, the CRISPR/Cas9 system is simpler, more accessible, and highly efficient for precise DNA modifications. This review examines CRISPR’s applications, particularly its potential in treating hereditary and chronic diseases. CRISPR technology offers advancement in treating diseases such as sickle cell disease, beta-thalassemia, haemophilia, cystic fibrosis, Duchenne muscular dystrophy, cardiovascular diseases, diabetes, and cancer. CRISPR enhances detection methods for infectious diseases like tuberculosis, human immunodeficiency virus and hepatitis B. By integrating CRISPR technology into healthcare, significant advancements can be made in the treatment and prevention of genetic diseases

Date: 2025
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