Haemo and Biochemical Changes in the Evaluation of Antimalarial Drugs as Therapeutic Alternatives to Mainstream Trypanosides in Experimentally Induced Trypanosomosis in Wistar Rats

N.n Pilau, U.m Mera, Zaid Shehu, A.e Okpan-Omo and A.e Dahunsi
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N.n Pilau: Department of Veterinary Medicine, Usmanu Danfodiyo University Sokoto
U.m Mera: Department of Veterinary Medicine, Usmanu Danfodiyo University Sokoto
Zaid Shehu: Department of Veterinary Medicine, Usmanu Danfodiyo University Sokoto
A.e Okpan-Omo: Health Service Department, Usmanu Danfodiyo University Sokoto
A.e Dahunsi: Department of Veterinary Public Health and Preventive Medicine, University of Abuja

International Journal of Research and Innovation in Applied Science, 2025, vol. 10, issue 6, 1867-1879

Abstract: This study evaluated the haematological and biochemical effects of antimalarial drugs as therapeutic alternatives to conventional trypanocides in Wistar rats experimentally infected with Trypanosoma brucei brucei, T. congolense, and T. vivax. Although parasite suppression and clinical signs were recorded, they are not included in this manuscript. Fifty-four adult rats were randomly assigned into three experimental models: (A) infected then treated, (B) treated before infection, and (C) infected but untreated. Each model consisted of six groups, with three replicates per group, each comprising three rats, adhering to the 3Rs principle. Rats were inoculated intraperitoneally with 5 × 10⠴ trypanosomes/mL and sampled at 60, 120, and 180 minutes post-infection. Haematological parameters (PCV, RBC, Hb, WBC) were measured from heparinized blood, while serum biochemical indices; serum creatinine, AST, ALT, ALP, BUN, bilirubin, total glucose (tGL), total protein, total cholesterol (TCH), and HDL were assessed from non-heparinized blood using automated analyzers. Significant (P

Date: 2025
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