Hematological and Renoprotective Effects of Chia (Salvia Hispanica) and Flax (Linum Usitatissimum) Seeds in a Monosodium Glutamate-Induced Oxidative Stress in Wistar Rats

Patience N Iloh, Jonathan C. Ifemeje, A.c Nwaka, Onyinye. J. Ofomata and Chinwe C. Ezeuchu
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Patience N Iloh: Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State 431124, Nigeria.
Jonathan C. Ifemeje: Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State 431124, Nigeria.
A.c Nwaka: Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State 431124, Nigeria.
Onyinye. J. Ofomata: Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Uli, Anambra State 431124, Nigeria.
Chinwe C. Ezeuchu: Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.

International Journal of Research and Innovation in Applied Science, 2025, vol. 10, issue 7, 1028-1038

Abstract: This study examined the effects of dietary chia and flaxseed supplementation on hematological parameters and kidney function in Wistar rats exposed to monosodium glutamate (MSG)-induced oxidative stress. Forty-eight male Wistar rats (120–150 g) were randomly divided into seven groups (n=5 each). Group A served as control (saline), Group B received MSG (15 mg/kg), and Groups C to F were given MSG along with either 20% or 40% chia or flax seeds. Group G received a combination of 20% chia and 20% flax seeds with MSG. After four weeks of oral treatment, blood samples were analyzed for hematological indices, including HGB, HCT, RBC, PLT, MCV, MCH, MCHC, MPV, and differential WBC counts, as well as kidney function markers such as serum urea, creatinine, and total protein. MSG significantly disrupted hematological and renal parameters. However, supplementation with chia and flax seeds significantly mitigated these effects (p

Date: 2025
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