Next Generation Detectors in Tandem Mass Spectroscopy: Innovations and Impact

Amtul Hafeez Gazala, Dr. K. Bhavya Sri and Mogili Sumakanth
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Amtul Hafeez Gazala: Research student department of pharmaceutical analysis, RBVRR women’s college of pharmacy, Barkatpura Hyderabad-500027, India.
Dr. K. Bhavya Sri: Associate Professor, Department of pharmaceutical analysis, RBVRR women’s college of pharmacy, Barkatpura Hyderabad-500027, India.
Mogili Sumakanth: Professor and Principal Department of pharmaceutical chemistry, RBVRR women’s college of pharmacy, Barkatpura Hyderabad-500027, India

International Journal of Research and Innovation in Applied Science, 2025, vol. 10, issue 7, 1654-1661

Abstract: Tandem mass spectrometry (MS/MS) has emerged as an indispensable analytical tool in proteomics, metabolomics, and pharmaceutical research due to its superior sensitivity, specificity, and resolution. The cornerstone of MS/MS performance lies in the detector technology, which enables accurate identification and quantification of ions. This review explores recent advancements in detector systems such as time-of-flight (TOF), Orbitrap, and ion trap technologies. These innovations have significantly enhanced analytical capabilities by improving resolution, dynamic range, ion detection limits, and fragmentation analysis. Hybrid detectors, which combine strengths of multiple systems, offer broader mass range coverage and facilitate high-throughput analyses. The integration of sophisticated data processing algorithms with these detectors has increased reliability while reducing noise, thereby refining the accuracy of results. Furthermore, miniaturized and robust detectors are pushing the boundaries of portable MS applications, with implications for on-site diagnostics, environmental monitoring, and forensic investigations.

Date: 2025
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