Antiplasmodial Potential and Phytochemical Evaluation of Aqueous Root Extract of a Nigerian Medicinal Apocynaceae Plant

Chidiebere A. Otuu, BRose N. N. Obiezue, Chris I. Okoye, Innocent C. J. Omalu, Ada Q. A. Otuu, Samuel S.Eke, Emmanuel. O. Udeh, Suleiman C. Hassan, Hadijah U. Yamman and Fabian C. Okafor
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Chidiebere A. Otuu: Parasitology and Public Health Unit, Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria
BRose N. N. Obiezue: Parasitology and Public Health Unit, Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria
Chris I. Okoye: Parasitology and Public Health Unit, Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria
Innocent C. J. Omalu: Department of Animal Biology, Federal University of Technology, Minna, Niger State, Nigeria.
Ada Q. A. Otuu: Department of Public Health, West African Postgraduate College of Pharmacists, Yaba, Lagos State. Department of Pharmacy, Alex Ekwueme Federal University Teaching Hospital Abakaliki, Ebonyi State, Nigeria.
Samuel S.Eke: Department of Biology, Air Force Institute of Technology, Kaduna, Kaduna State, Nigeria.
Emmanuel. O. Udeh: Centre for Integrated Health Programs, Wuse 2, Federal Capital Territory, Abuja, Nigeria..
Suleiman C. Hassan: Department of Zoology, Nasarawa State University, Keffi, Nigeria.
Hadijah U. Yamman: Department of Animal Biology, Federal University of Technology, Minna, Niger State, Nigeria.
Fabian C. Okafor: Parasitology and Public Health Unit, Department of Zoology and Environmental Biology, University of Nigeria, Nsukka, Enugu State, Nigeria

International Journal of Research and Innovation in Applied Science, 2021, vol. 6, issue 5, 57-61

Abstract: The increasing resistance of the malaria parasite to currently used antimalarial medicines has intensified the research for new novel antimalarial drug leads from natural sources. This study was carried out to evaluate the antiplasmodial potential, phytochemical composition and toxicity status of aqueous root extract of Alstoniaboonei (Apocynaceae), a medicinal plant used in treating malariain Nigeria and other African countries. The extract showed substantial dose dependent antiplasmodial activity as indicated by the, suppressive (40.18%, 55.72% and 61.55% for 100, 200 and 400 mgkg-1 body weights), prophylactic (51.39%, 65.27% and 68.35% for 100, 200 and 400 mgkg-1 body weights), and curative (48.63%, 59.59% and 60.88% for 100, 200 and 400 mgkg-1 body weights) effects on Plasmodium berghei infected albino mice. The antiplasmodial activity was significantly different compared to the negative control at P

Date: 2021
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