Sub-Acute Toxicity Assessment of a Polyherbal Product “Combo†on Liver and Kidney Function Indices in Experimental Rats

Azeemat Titilola Abdulazeez, Akolade Jubril Olayinka, Fatimah Aluko Abubakar and Balogun Basheer Ajibola
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Azeemat Titilola Abdulazeez: Department of Biological Sciences, Al-Hikmah University, Ilorin, Nigeria
Akolade Jubril Olayinka: Biotechnology Advanced Research Centre, Sheda Science and Technology Complex, Abuja, Nigeria
Fatimah Aluko Abubakar: Department of Biochemistry, University of Ilorin, Ilorin, Nigeria
Balogun Basheer Ajibola: Department of Biochemistry, University of Ilorin, Ilorin, Nigeria

International Journal of Research and Innovation in Applied Science, 2021, vol. 6, issue 8, 41-45

Abstract: “Combo†is a standardized polyherbal drink prepared from five different medicinal plants. It is popularly used in Nigeria, mostly by women for reproductive and sexual dysfunction. Due to its widespread appeal to trying to conceive (TTC) patients and long-time abuse as an aphrodisiac, the effect of sub-acute administration of combo for 28 days on liver and kidney function indices in experimental rats was investigated. Serum biochemical indices and hematological parameters were determined and compared for significant variation with a reference group. In contrast to traditional belief among users, oral administration of Combo to rats once a day for 28 days at either 100, 200 or 300 mg/Kg bw did not lead to a significant (p

Date: 2021
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