Aqueous Extract of Date Fruit (Phoenix Dactylifera) Has Hepatocurative Effect on Carbon Tetrachloride-Induced Toxicity in Rats

Misbahu Sambo, Selfira Salsabilla, Abdulqadir Yunusa, Usman Yunusa, Abdullahi Garba Jakwa, Isah Labaran and Abubakar Bawa
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Misbahu Sambo: Department of Biochemistry, Abubakar Tafawa Balewa University, Bauchi, Nigeria. Molecular Genetics and Infectious Diseases Research Laboratory, Abubakar Tafawa Balewa University, Bauchi, Nigeria.
Selfira Salsabilla: Fakultas Manajemen Pertahanan, Universitas Pertahanan Republik Indonesia
Abdulqadir Yunusa: Department of Science Laboratory Technology, Federal Polytechnic Mubi, Adamawa State, Nigeria.
Usman Yunusa: Biochemistry Division, National Veterinary Research Institute, Vom, Plateau State, Nigeria.
Abdullahi Garba Jakwa: Department of Biochemistry, Abubakar Tafawa Balewa University, Bauchi, Nigeria..
Isah Labaran: Department of Science Laboratory Technology, Federal Polytechnic Mubi, Adamawa State, Nigeria.
Abubakar Bawa: Department of Science Laboratory Technology, Federal Polytechnic Mubi, Adamawa State, Nigeria.

International Journal of Research and Innovation in Applied Science, 2022, vol. 7, issue 11, 50-53

Abstract: Liver disease account for a reasonable percentage of medical admissions, and the synthetic drugs used for the treatment of the disease are sometimes ineffective and/or very expensive. Furthermore, the side effects associated with some of them are numerous. These and many other reasons shifted the interest of scientists for the search of plants with hepatocurative effect. Therefore, the aim of this research was to investigate the curative effect of aqueous extract of date fruit (Phoenix dactylifera) on rats with carbon tetrachloride-induced hepatotoxicity. The serum level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), direct bilirubin (DB) and total bilirubin (TB) were measured as markers of liver disease using standard methods, and compared among group I (Negative control), group II (Positive control), group III (Fed with food + 249mg/kg of extract), group IV (Fed with food + 580mg/kg of extract), group V (hepatotoxic rats treated with 249mg/kg of extract) and group VI (hepatotoxic rats treated with 580mg/kg of extract). The results showed that administration of the various concentration of the extract to healthy rats does not cause any harm to the liver. Also, the different concentrations of the extract significantly (P

Date: 2022
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