Cannabis Sativa: One-Plant-One-Medicine for Many Diseases-Therapeutic Uses-A Review of Evidence

Ravindra B. Malabadi, Raju K. Chalannavar, Kiran P. Kolkar, Gholamreza Abdi, Antonia Neidilê Ribeiro Munhoz and Himansu Baijnath,
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Ravindra B. Malabadi: Department of Applied Botany, Mangalore University, Mangalagangotri-574199, Mangalore, Karnataka State, India
Raju K. Chalannavar: Department of Applied Botany, Mangalore University, Mangalagangotri-574199, Mangalore, Karnataka State, India
Kiran P. Kolkar: Department of Botany, Karnatak Science College, Dharwad-580003, Karnataka State, India
Gholamreza Abdi: Department of Biotechnology, Persian Gulf Research Institute, Persian Gulf University, Bushehr, 75169, Iran
Antonia Neidilê Ribeiro Munhoz: Department of Chemistry, Environment and Food, Federal Institute of Amazonas, Campus Manaus Centro, Amazonas, Brazil- 69020-120
Himansu Baijnath,: Ward Herbarium, School of Life Sciences, University of KwaZulu-Natal, Westville Campus, Private Bag X54001, Durban 4000, South Africa

International Journal of Research and Innovation in Applied Science, 2023, vol. 8, issue 8, 132-174

Abstract: This present review highlights the efficacy and therapeutic uses of Cannabis on the basis of ongoing and proven clinical trials. Since from 5,000 years ago the parts of cannabis plant was used by medicinal practitioners from India and regularly used to cure various diseases, syndromes and disorders. Nabilone is a synthetic cannabinoid approved for treatment of severe nausea and vomiting associated with cancer chemotherapy. Cannabidiol (CBD) and its metabolite 7-OH-CBD, but not THC or other congeneric cannabinoids tested, potently block SARS-CoV-2 replication in lung epithelial cells. Cannabis has a bronchodilator effect on the airways and might have an anti-inflammatory effect, yet there are many harmful effects on the lungs of asthmatic patients. Cannabis sativa-based cream on Cutaneous leishmaniasis (CL) associated skin lesions promoted the healing process. Cannabis oil was used as a body lotion for controlling monkeypox viral disease. However, there are some adverse reactions and insignificant effect of medical Cannabis and hemp was also noticed in the treatment of diseases. Cannabis and Cannabinoid drugs are widely used to treat disease or alleviate symptoms, but their efficacy for specific indications is not clear. Furthermore, the clinical results remained controversial and warranted further investigation.

Date: 2023
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