Haematinic Activity of Sesamum Indicum Seed Oil with Leaf Extract on Anaemic-Induced Ratsediale Aimanose Love

Opeyemi Olufeyisola Adesina, Aimanose Love Ediale and Oluwafemi Adewale Adesina
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Opeyemi Olufeyisola Adesina: Department of Medical Laboratory Science, Babcock University, Ilishan, Ogun State, Nigeria
Aimanose Love Ediale: Department of Medical Laboratory Science, Babcock University, Ilishan, Ogun State, Nigeria
Oluwafemi Adewale Adesina: Department of Oral and Maxillofacial Surgery, College of Medicine, Lagos State University, Ikeja, Nigeria

International Journal of Research and Innovation in Applied Science, 2024, vol. 9, issue 11, 61-71

Abstract: Background: Anaemia is a global health issue affecting millions, especially in developing countries. Sesamum indicum (sesame) seed oil and leaf extract are known for their nutritional and medicinal properties. This study investigates their haematinic effects on anaemic-induced Wistar rats. Methods: The seed and leaf of Sesamum indicum were authenticated and processed. Seed oil was extracted using hexane and leaf extract was obtained via soxhlet extraction with ethanol. Thirty Wistar rats were divided into six groups (n=5): Group 1 (normal control), Group 2 (anaemic control), Group 3 (positive control treated with Vitamin B12), Group 4 (treated with seed oil), Group 5 (treated with leaf extract), and Group 6 (treated with both seed oil and leaf extract). Anaemia was induced in Groups 2-6 with 20 mg/kg of 2,4-dinitrophenylhydrazine (DNPH). The treatment lasted 10 days. Blood samples were analyzed for haemoglobin (HB), packed cell volume (PCV), red blood cell count (RBC), and other parameters using a Sysmex XE-2100 automated analyser. Data were analyzed using SPSS version 21 with ANOVA and post-hoc tests. Results: Significant improvements in haematological parameters were observed in the treated groups compared to the anaemic control. Group 6 (combined oil and extract) showed the highest increase in haemoglobin (13.97±1.0 g/dL), PCV (38.33±2.8%), and RBC count (8.28±0.3 x10⠶/mm³). Statistical analysis revealed significant differences in HB (p=0.002), PCV (p

Date: 2024
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