Evaluation of Phytochemical and Antidiabetic Potentials of Aqueous, Ethanol, and Acetone Crude Extracts of Plectranthus Neochilus Leaves on Alloxan Induced Diabetic Wistar Rats

Ephraim O. Abu and Alexander O. Edah
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Ephraim O. Abu: Department of Chemistry, Faculty of Natural Sciences,University of Jos, Nigeria
Alexander O. Edah: Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences,University of Jos, Nigeria

International Journal of Research and Innovation in Applied Science, 2024, vol. 9, issue 2, 16-28

Abstract: Diabetes mellitus is a metabolic disorder which leads to abnormally high blood glucose level (hyperglycemia). This research work is aimed at evaluating the antidiabetic potentials of aqueous, ethanol and acetone extracts of plectranthus neochilus leaves on alloxan induced diabetic wistar rats. Materials and Methods:The experimental rats were induced and made diabetic by single intra-peritoneal administration of Alloxan monohydrate at a dose rate of 150 mg/kg dissolved in 0.9% freshly prepared normal saline at pH 5.5. Sixty-five adult (male) albino rats weighing 160-200g were used for this study. The Animals were divided into 12 groups of 5 rats each namely: A: Normal control, B: Diabetic control 150kg/body weight of alloxan, C: Diabetic + 1000mg/kg body weight of Standard drug (Metformin), D: Diabetic + 250mg/kg body weight of aqueous extract, E: Diabetic + 500mg/kg body weight of aqueous extract, F: Diabetic + 1000mg/kg body weight of aqueous extract, G: Diabetic + 250mg/kg body weight ethanol extract, H: Diabetic + 500mg/kg body weight of ethanol extract, I: Diabetic + 1000mg/kg body weight of ethanol extract, J: Diabetic + 250mg/kg body weight of acetone extract, K: Diabetic + 500mg/kg body weight of acetone extract, L: Diabetic + 1000mg/kg body weight of acetone extract. The extracts were administered orally for a duration of 28days at doses of (250, 500, and 1000 mg/kg body weight). Results:Treatment with extracts significantly reduced (p

Date: 2024
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