A Phorbol Ester from Antimicrobial and Anthelmintic Leaf Extracts of Pseudocedrela Kotschyi Chweinf Harms (Meliaceae)

S. K. Okwute and O. U. Onyekwere
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S. K. Okwute: Department of Chemistry, University of Abuja, P.M.B. 117, Gwagwalada, Abuja, F.C.T Department of Pure and Applied Chemistry, Veritas University, Bwari, Abuja, F. C. T.
O. U. Onyekwere: Department of Chemistry, University of Abuja, P.M.B. 117, Gwagwalada, Abuja, F.C.T

International Journal of Research and Innovation in Applied Science, 2024, vol. 9, issue 3, 274-282

Abstract: The powdered dry leaf of Pseudocedrela kotschyi was successively extracted with n-hexane, chloroform, 30% aqueous ethanol and methanol. Phytochemical screening of the extracts showed the presence of saponins, tannins, alkaloids, glycosides, cardiac glycosides, flavonoids, phenols and anthraquinones. Antimicrobial screening of the extracts revealed activity against Staphylococcus aureus, Escherichia coli, Streptococcus pneumonia, Proteus vulgaris, Candida albicans and Pseudomonas aeruginosa with mic values ranging from 100-250 µg/ml. Also, the anthelmintic activity of the extracts against the pin worm, Entrobius vermicularis and the earth worm, Lumbricina terrestris was investigated and they displayed generally high anthelmintic activity. Chromatographic fractionation ,followed by GC-MS analysis of the fractions led to the identification of phorbol-12,13-dihexanoate as a constituent of the leaves of P. kotschyi. This may account for the highly poisonous property of the plant.

Date: 2024
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