Phytochemical and Anti-Diarrhoeal Potential of Ipomea batatas Leaf Solvent Extract on Castor Oil Induced Diarrhoeal Rat Model

Muazu Alkali Adamu, Suleiman Ali and Musa Magaji Jawa
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Muazu Alkali Adamu: Department of Science Laboratory Technology, School of Sciences, Yobe State College of Agriculture Science and Technology, Gujba, Yobe, Nigeria.
Suleiman Ali: Department of Science Laboratory Technology, School of Sciences, Yobe State College of Agriculture Science and Technology, Gujba, Yobe, Nigeria.
Musa Magaji Jawa: Department of Science Laboratory Technology, School of Sciences, Yobe State College of Agriculture Science and Technology, Gujba, Yobe, Nigeria.

International Journal of Research and Innovation in Applied Science, 2024, vol. 9, issue 6, 271-286

Abstract: The folkloric claim of Ipomoea batatas extracts in the management of diarrhoea is yet to be substantiated or refuted with scientific data. Therefore, the present study was aimed to screen the extracts of I. batatas for both its secondary metabolites, acute toxicity, and antidiarrhoeal activity at 125, 250, and 500 mg/kg body weight in rats and elemental analysis of the most active extract. The most active extract was screened for elemental analysis. Secondary metabolites were screened using standard methods while the antidiarrhoeal activity was done by adopting the castor oil-induced diarrhoeal and castor oil-induced enteropooling, models. The extracts contained flavonoids, phenolics, saponins, alkaloids, tannins, terpenes, and steroids were detected. The LD50 of extracts were found to be greater than 5000mg per kg body weight of the rats. The elemental analysis revealed the presence of potassium, zinc, sodium, and chloride. In the castor oil-induced diarrhoeal model, the extracts significantly (𠑃

Date: 2024
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