Evaluation of Some Renal Biomakers in Patients with Benign Prostatic Hyperplasia/Prostate Cancer Attending Nnamdi Azikiwe University Teaching Hospital Nnewi

Anthonia Chinenye Ogueze, Nancy Amara Mbachu, Augustine Chinedu Ihim, Ejike Christian Onah, Nkiruka Chinenye Nwoka, Stellamaris Chinenye Okeke, Juliet Chinonso Akaeme and Chiazoka Frances Nduka
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Anthonia Chinenye Ogueze: Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Nancy Amara Mbachu: Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Augustine Chinedu Ihim: Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Ejike Christian Onah: Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Nkiruka Chinenye Nwoka: Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Stellamaris Chinenye Okeke: Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Juliet Chinonso Akaeme: Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
Chiazoka Frances Nduka: Department of Clinical Chemistry, Faculty of Medical Laboratory Science, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.

International Journal of Research and Innovation in Applied Science, 2024, vol. 9, issue 8, 413-421

Abstract: Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are among the urological conditions that affect aging men. Patients with this pathology could develop renal impairment. Renal biomarkers like beta-2-microglobulin (BMG), urea, urine creatinine, microalbumin (MALB), and albumin to creatinine ratio (ACR) were assessed with total (tPSA) and free prostate specific antigen (fPSA), systolic blood pressure (SBP), diastolic blood pressure (DBP), height, weight and BMI. This cross sectional study recruited 120 men using convenient sampling technique which comprised 40 BPH, 40 PCa and 40 control attending Urology Clinic of NAUTH Nnewi, Anambra State. Five (5) milliliters of blood/ urine samples were collected from the patients and the necessary data were obtained from clinical records of the patients. The weight (kg) and height (m) were measured using standard beam balance scale and a stadiometer respectively and the BMI calculated. Blood pressure was measured using sphygmomanometer and stethoscope. PSA (ng/ml) was estimated by Enzyme immunoassay technique, BMG (mg/l) and MALB (mg/l) by immunoturbidimetric method, urea and creatinine were determined spectrophotometrically using modified Urease-Berthelot method and Jaffe slot alkaline picrate method respectively. Data analysis was conducted using SPSS version 21.0. The results were presented as median. Kruskal Wallis was used to determine significant differences between the mean values. P

Date: 2024
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