Pharmacological Review of Drug Interactions

Leo Clinton Chukwu, Sylvester Onuegbunam Nweze, Benjamin Uzodinma Chukwuka, Malachy Ezenwaeze Nwaeze, Malachy Chukwuma Nwankwo, Obigwe Innocent Maduabuchi, Chidinma Cornelle Okany, Kenneth Ikechukwu Nwadike and Okoro Peace Ngozi
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Leo Clinton Chukwu: College of Medicine, Chukwuemeka Odumegwu Ojukwu University, Awka Nigeria Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medicine, Chukwuemeka Odumegwu Ojukwu University, Awka Nigeria.
Sylvester Onuegbunam Nweze: Department of Obstetrics and Gynecology, College of Medicine, Enugu State University, (ESUCOM), Enugu, Nigeria.
Benjamin Uzodinma Chukwuka: Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria.
Malachy Ezenwaeze Nwaeze: Department of Pharmacology and Therapeutics, College of Medicine, Enugu State University of Science and Technology, Enugu State, Nigeria.
Malachy Chukwuma Nwankwo: Department of Obstetrics and Gynecology, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria.
Obigwe Innocent Maduabuchi: Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Medicine, Chukwuemeka Odumegwu Ojukwu University, Awka Nigeria.
Chidinma Cornelle Okany: The Alex Community Health Clinic, Calgary Alberta, Canada.
Kenneth Ikechukwu Nwadike: Department of Pharmacology and Therapeutics, University of Nigeria, Enugu Campus Enugu Nigeria.
Okoro Peace Ngozi: Department of Pharmacology and Therapeutics, David Umahi Federal University of Health Sciences, Uburu Ebonyi State Nigeria.

International Journal of Research and Innovation in Applied Science, 2024, vol. 9, issue 9, 312-323

Abstract: Drug interaction (DI) occurs when the effects of one drug are altered by the presence of another drug, herbal medicine, foods, drink or by some environmental or chemical agents†. Any time a drug is administered with another prescription or over the counter drug, herb or food item, there is the risk of interactions which may be potentially dangerous. Drug-drug interaction increases with the number of drugs used concomitantly. The drug whose activity is effected by such interaction is referred to as the “Object drug†while the agent that eventually precipitates such an interaction is referred to as the “Precipitant / Perpetrator drug†. It is worthy of note that drug interactions may cause drugs to be less effective, may induce unexpected side effects or rarely even increase the action of a particular drug. Many drug interactions have been found to be harmful. Approximately 3– 26% of adverse reactions related to hospital admissions are due to drug-drug interactions while, global prevalence of potentially inappropriate prescribing ranges from 13–35%.

Date: 2024
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