Detecting familial defective apolipoprotein B-100 R3500Q in Vietnamese patients by PCR-sequencing

Bui Van Cong, Nguyen Thi Nga, Pham Nguyen Oanh Vu and Truong Kim Phuong ()
Additional contact information
Bui Van Cong: Univerity of Science, Vietnam National University Ho Chi Minh City, Vietnam
Nguyen Thi Nga: Ho Chi Minh City Open University, Vietnam
Pham Nguyen Oanh Vu: Ho Chi Minh City Open University, Vietnam
Truong Kim Phuong: Ho Chi Minh City Open University, Vietnam

HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, 2016, vol. 6, issue 1, 43-50

Abstract: Familial defective apolipoprotein B-100 (FDB) is an autosomal codominant disorder associated with hypercholesterolemia, caused by mutations in and around codon 3500 of the Apolipoprotein (Apo) B gene, which encodes Apo B-100. The first mutation occurred in Arginine codons to be described, and the most characterized, is caused by a G→A transition at nucleotide 10,708 and results in the substitution of Arginine by Glutamine at codon 3500 (ApoB R3500Q). In this study, we have identified 27 R3500Q mutations in known FDB patients using PCRSequencing method. As the result, most of the patients carried heterozygous mutation R3500Q. PCR-Sequencing method that we have applied in this study proved consistent and so easily identified mutations correctly.

Keywords: Apoliprotein B-100; familial defective; ApoB R3500Q (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journalofscience.ou.edu.vn/index.php/tech-en/article/view/405/335 (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bjw:techen:v:6:y:2016:i:1:p:43-50

Access Statistics for this article

HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY is currently edited by Nguyen Thuan

More articles in HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY from HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY
Bibliographic data for series maintained by Vu Tuan Truong ().