The initial study of EBNA-2 polymorphisms in nasopharyngeal carcinoma in Vietnam

Ngo Dong Kha, Huynh Thi Mong Tuyen, Lam Hong Ngoc, Thieu Hong Hue, Le Quang Anh Tuan, Lao Duc Thuan and Le Huyen Ai Thuy ()
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Ngo Dong Kha: University of Science, Vietnam National University Ho Chi Minh City, Vietnam
Huynh Thi Mong Tuyen: Ho Chi Minh City Open University, Vietnam
Lam Hong Ngoc: Ho Chi Minh City Open University, Vietnam
Thieu Hong Hue: Ho Chi Minh City Open University, Vietnam
Le Quang Anh Tuan: Ho Chi Minh City Open University, Vietnam
Lao Duc Thuan: Ho Chi Minh City Open University, Vietnam
Le Huyen Ai Thuy: Ho Chi Minh City Open University, Vietnam

HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, 2018, vol. 8, issue 1, 60-67

Abstract: Epstein-Barr virus (EBV) infection is the main cause of Nasopharyngeal Carcinoma (NPC). EBNA-2, one of the most important genes participating in the formation of NPC, also helps EBV evade an attack on the immune system. EBNA-2 has 4 variants including E2-A, E2-B, E2-C and E-2D, of which E2-A and E2-C are the characterized variants for NPC. This study aimed to evaluate the variations of EBNA-2 in NPC biopsy samples of Vietnamese patients. This initial study used 10 biopsy samples, which were positively confirmed to NPC, collected from Cho Ray Hospital. Nested PCR – nucleotide sequencing was applied to analyze the variants of EBNA-2. The results showed that 8 out of 10 samples, accounting for 80%, were positive to EBNA-2. Additionally, only two variants, E-2A and E-2C were detected in our study, in which, E2-A subtype was identified as the predominant subtype. These findings would provide initial data about potential contribution of EBNA-2 polymorphisms to etiology of NPC in Vietnamese population.

Keywords: E-2A; E-2C; EBNA-2; nasopharyngeal carcinoma; SNPs (search for similar items in EconPapers)
Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:bjw:techen:v:8:y:2018:i:1:p:60-67

DOI: 10.46223/HCMCOUJS.tech.en.8.1.337.2018

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