Methylation of Ecadherin gene is correlated with increased risk of nasopharyngeal carcinoma: A meta-analysis

Truong Kim Phuong (), Lao Duc Thuan, Nguyen Thi Hoang Trinh, Nguyen Thi Phuong Dieu and Nguyen Thi Le
Additional contact information
Truong Kim Phuong: Ho Chi Minh City Open University, Vietnam
Lao Duc Thuan: Ho Chi Minh City Open University, Vietnam
Nguyen Thi Hoang Trinh: Ho Chi Minh City Open University, Vietnam
Nguyen Thi Phuong Dieu: Ho Chi Minh City Open University, Vietnam
Nguyen Thi Le: Ho Chi Minh City Open University, Vietnam

HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, 2019, vol. 9, issue 1, 28-40

Abstract: Background: The objective of this study was to estimate the correlation between the Ecadherin (CDH1) promoter methylation and the risk of nasopharyngeal cancer. Methods: Based on previous online articles for the evaluation the hypermethylated status of CDH1 gene at the promoter region with nasopharyngeal carcinoma, two independent reviewers selected studies through databases on PubMed, Google Scholar from 2001 to 2014. The software MedCalc® version 18.11 was applied for calculating pooled odd ratios (OR) with levels of data heterogeneity by the fixed and random effects models. Results: Of a total of 99 articles, 12 studies with 508 clinical samples of nasopharyngeal carcinoma patients and 282 normal samples were selected in the systematic review for meta-analysis. Overall, the results demonstrated the highly significant association between CDH1 promoter methylation with nasopharyngeal carcinoma under the fixed effects model (OR = 16.155, 95% CI: 8.533 - 30.585, p 0.001). Conclusion: This study proposed the strong association between CDH1 promoter methylation and the risk of nasopharyngeal carcinoma in Asia and other populations. For this reason, the abnormal methylation in CDH1 gene should be a potential hallmark of prognosis and diagnosis for nasopharyngeal carcinoma.

Keywords: DNA methylation; Ecadheringene; meta-analysis; nasopharyngeal carcinoma (search for similar items in EconPapers)
Date: 2019
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journalofscience.ou.edu.vn/index.php/tech-en/article/view/349/278 (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:bjw:techen:v:9:y:2019:i:1:p:28-40

DOI: 10.46223/HCMCOUJS.tech.en.9.1.349.2019

Access Statistics for this article

HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY is currently edited by Nguyen Thuan

More articles in HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY from HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE, HO CHI MINH CITY OPEN UNIVERSITY
Bibliographic data for series maintained by Vu Tuan Truong ().