Applied bioinformatics tools for analysis of Microrna-214 expression and prediction of its potential targets genes in Nasopharyngeal carcinoma

Nguyen Hoang Danh, Thieu Hong Hue, Quang Trong Minh, Trong Nghia K', Nguyen Thanh Tung, Phan Dang Hoang Nam, Tran Hoang Bao Tran and Lao Duc Thuan ()
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Nguyen Hoang Danh: Ho Chi Minh City Open University, Vietnam
Thieu Hong Hue: University of Science, Vietnam National University Ho Chi Minh City, Vietnam
Quang Trong Minh: Ho Chi Minh City Open University, Vietnam
Trong Nghia K': Ho Chi Minh City Open University, Vietnam
Nguyen Thanh Tung: Ho Chi Minh City Open University, Vietnam
Phan Dang Hoang Nam: Ho Chi Minh City Open University, Vietnam
Tran Hoang Bao Tran: Ho Chi Minh City Open University, Vietnam
Lao Duc Thuan: Ho Chi Minh City Open University; University of Science, Vietnam National University Ho Chi Minh City, Vietnam

HO CHI MINH CITY OPEN UNIVERSITY JOURNAL OF SCIENCE - ENGINEERING AND TECHNOLOGY, 2019, vol. 9, issue 1, 3-13

Abstract: miRNA (microRNA) are short RNA molecules in length from 20 to 24 nucleotides that have been shown to play an important role in regulating gene expression in many different types of human cancer. Meanwhile, miRNA-214 is one of the known miRNAs involved in the formation of nasopharyngeal carcinoma (NPC) through overexpression that promotes proliferation and development of cancer cells. However, in Vietnam, the study of miR-214 related to NPC has not been conducted yet. With the aims to develop the further studies of miR-214 on NPC in Vietnamese patients, in this initial study, we conducted the analysis of miR-214 expression in previous publications, as well as the prediction of miR-214 potential target genes, which involved in many cellular pathways. Here we applied bioinformatics tools to predict miRNAs and their targets, and discuss the role of miR-214 in the context of human cancers. As the results, miR-214 acted as the oncogenic roles in NPC, relevanted to many pathways, such as cell proliferation, apoptosis, metastasis and invasion through the its target genes LTF, Bim, Bax, LINC0086, etc. In conclusion, the use of computional approaches facilitate the further experimental validation of miRNAs in general, particularly miR-214, in Vietnamese NPC patients.

Keywords: microRNA; miRNA-214; Nasopharyngeal carcinoma (search for similar items in EconPapers)
Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:bjw:techen:v:9:y:2019:i:1:p:3-13

DOI: 10.46223/HCMCOUJS.tech.en.9.1.347.2019

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