Adjusting for Regression Effect in Uncontrolled Studies

Joshua D. Naranjo and Joseph W. McKean

Biometrics, 2001, vol. 57, issue 1, 178-181

Abstract: Summary. When clinical studies require enrolled patients to have abnormal assays, the natural tendency of repeat measurements to regress toward the mean can lead to a false assessment of effectiveness of therapy. We propose a method to more accurately estimate the true effect of therapy by adjusting for a component of improvement that can be attributed to regression effect. The model we use allows for a combination of additive and/or multiplicative effects of the therapy.

Date: 2001
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