Comparing Treatments in the Presence of Crossing Survival Curves: An Application to Bone Marrow Transplantation

Brent R. Logan, John P. Klein and Mei‐Jie Zhang

Biometrics, 2008, vol. 64, issue 3, 733-740

Abstract: Summary In some clinical studies comparing treatments in terms of their survival curves, researchers may anticipate that the survival curves will cross at some point, leading to interest in a long‐term survival comparison. However, simple comparison of the survival curves at a fixed point may be inefficient, and use of a weighted log‐rank test may be overly sensitive to early differences in survival. We formulate the problem as one of testing for differences in survival curves after a prespecified time point, and propose a variety of techniques for testing this hypothesis. We study these methods using simulation and illustrate them on a study comparing survival for autologous and allogeneic bone marrow transplants.

Date: 2008
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